Sophia Loren, Richard Harris, Ava Gardner, Burt Lancaster, Martin Sheen, O.J. Simpson, Lee Strasberg, Ingrid Thulin and John Phillip Law star in this terrifying odyssey of a plague-infested train, speeding across Europe to the Cassandra Crossing...and death.
When a plague-infected terroist, fleeing from the police, exposes the 1,000 riders of the Geneva to Stockholm Express, Colonel MacKenzie (Lancaster) is called in to handle the situation. He loates a doctor aboard the train, Jonathan Chamberlain (Harris) who, with his wife (Loren) finds the fugitive. They attempt to transfer him to a hovering helicoper, but fail, and the terrorist dies. To prevent the spread of the plague, Colonel MacKenzie directs the train to the Cassandra Crossing where it will plunge to oblivion, killing all aboard. At Nuremberg, the train is pumped with oxygen and the stricken passengers begin to recover. Dr. Chamberlain argues that they be spared, but Colonel MacKenzie refuses, and as the train rushes towards the collapsing Cassandra Crossing bridge, Chamberlain struggles to disconnect the cars and save the passengers from their appointment with doom.