Hugh Hathawat (Ed Harris) was captain of the high school football team when Aggie Snow (Diane Keaton) first went giddy over him. Now, he's a successful Senator running for Presdient and she's an award-winning children's author. They may clash on some political issues, but they can agree on one thing: they're falling in love.
Aggie isn't sure she's ready to become anyone's first lady, let alone the country's, but she's soon seduced by the smiling senator and introduced as his bride-to-be to the nation. Unfortunately for the White house hopefuls, someone has film footage of Aggie from the Nixon Years, showing her in a series of compromising positions which could compromise Hugh's chance of winning. Will the two running mates run into a brick wall - or will love conquer all before election day? Running Mates reveals all in a hilarious comedy about Washington behind closed doors.